Okay, I need to create a professional Wikipedia-style document about "Calcineurin Inhibitors" under the categories of Health, Medicine, and Drug Therapy. Let me start by understanding what calcineurin inhibitors are. From what I remember, they're a class of immunosuppressants used after organ transplants to prevent rejection. But I should verify that.

First, the structure: H1 for the title, then an overview section. Then sections with H2 and H3 headings. The user wants at least 800 characters, so I need to make sure each section is detailed enough.

For the introduction, I'll explain what calcineurin inhibitors are, their main function in suppressing the immune system, and their primary use in transplant patients. Maybe mention that they inhibit calcineurin, which is an enzyme involved in T-cell activation.

Next, the mechanism of action. I need to break down how they work. Calcineurin is part of the signaling pathway for T-cells. When it's inhibited, the production of cytokines like IL-2 is blocked, preventing T-cell proliferation. Maybe include a diagram or a simple explanation here. Also, mention that they are different from other immunosuppressants.

Then, types and examples. The main ones are cyclosporine and tacrolimus. I should list them with their chemical structures if possible, but since it's text, maybe just name them. Also, note any newer agents like everolimus or sirolimus, though those might be mTOR inhibitors. Wait, need to check that. Oh right, calcineurin inhibitors are specifically cyclosporine and tacrolimus. Everolimus is an mTOR inhibitor, so maybe not part of this category. I should clarify that.

Indications: Transplant rejection prevention (kidney, liver, heart), autoimmune diseases like rheumatoid arthritis or psoriasis. But need to confirm if they're used for those. Also mention other conditions where immune suppression is needed.

Adverse effects and monitoring: Common side effects include nephrotoxicity, hypertension, hyperkalemia, neurotoxicity. Monitoring parameters would be renal function tests (creatinine), blood pressure, electrolytes. Maybe discuss drug interactions, like with grapefruit juice affecting metabolism.

Dosage and administration: Oral vs IV, dosing frequency, need for therapeutic drug monitoring. Mention that levels are checked regularly to avoid toxicity.

Contraindications and precautions: Allergies to the drugs, severe renal impairment, pregnancy (since they can cause fetal harm). Also note interactions with other medications like antifungals or antibiotics.

References: Include some key studies or guidelines from reputable sources like WHO, FDA, or major medical journals. Maybe mention specific clinical trials if I can recall any.

I need to make sure the information is accurate and up-to-date. For example, confirm that cyclosporine and tacrolimus are indeed calcineurin inhibitors. Also check for any recent advancements in this class of drugs. Avoid using markdown except for headers and lists. Use simple language but include necessary medical terms with explanations.

Wait, the user mentioned to use H1, H2, H3. So the title is H1. Then sections like "개요/소개" as H2, then subsections under that as H3 if needed. But maybe the structure should be: Title (H1), Overview (H2), Mechanism of Action (H2), Types and Examples (H2), Indications (H2), Adverse Effects (H2), Dosage (H2), Contraindications (H2), References (H2). Each of these H2 sections can have H3 subsections if needed.

Also, need to ensure that each section is detailed enough. For example, under Mechanism of Action, explain the calcineurin pathway in T-cells, how inhibition stops IL-2 production, etc. Under Types and Examples, list cyclosporine, tacrolimus, maybe others like pimecrolimus or sirolimus (though those might be different classes). Wait, pimecrolimus is a calcineurin inhibitor but used topically for eczema. So include that as well.

Check if there are any other important points. Maybe mention the difference between cyclosporine and tacrolimus in terms of potency or side effects. Also, note that they are often used in combination with other immunosuppressants like corticosteroids or mycophenolate mofetil.

For adverse effects, elaborate on each: nephrotoxicity (how it affects kidneys), hypertension (mechanism?), hyperkalemia (why does it cause high potassium levels?), neurotoxicity (tremors, headaches). Also mention long-term risks like increased cancer risk due to immunosuppression.

In the dosage section, explain that dosing is individualized and monitored through blood tests. Mention therapeutic drug monitoring (TDM) as a key aspect.

Contraindications: Allergies, severe renal issues, pregnancy (especially first trimester), interactions with other drugs. Also note that they should not be used in patients with active infections.

References: Include sources like the FDA label for cyclosporine and tacrolimus, guidelines from the American Society of Transplantation, or studies published in journals like The New England Journal of Medicine.

I need to make sure all information is accurate. For example, confirm that calcineurin inhibitors are indeed used in autoimmune diseases beyond transplants. Maybe check if they're used for conditions like lupus or multiple sclerosis, but I think their primary use is in transplant and some specific autoimmune cases.

Also, mention that these drugs can increase the risk of infections due to immunosuppression, so patients need monitoring for opportunistic infections.

Avoid any markdown except for headers. Use bullet points for lists where appropriate. Make sure each section flows logically and covers all necessary aspects without being too technical but still professional.